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Review article| Volume 9, ISSUE 3, P202-206, July 2018

Additive manufacturing applications in orthopaedics: A review

Published:April 23, 2018DOI:https://doi.org/10.1016/j.jcot.2018.04.008
Additive manufacturing applications in orthopaedics: A review
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      Abstract

      The applications of Additive Manufacturing (AM) have increased extensively in the area of orthopaedics. The AM applications are for making anatomic models, surgical instruments & tool design, splints, implants and prosthesis. A brief review of various research articles shows that patient-specific orthopaedic procedures provide multiple applications areas and provide directions for future developments. The purpose of this paper is to identify the best possible usage of additive manufacturing applications in orthopaedics field. It also presents the steps used to prepare a 3D printed model by using this technology and details applications in the field of orthopaedics. AM gives a flexible solution in orthopaedics area, where customised implants can be formed as per the required shape and size and can help substitution with customised products. A 3D model created by this technology gain an accurate perception of patient's anatomy which is used to perform mock surgeries and is helpful for highly complex surgical pathologies. It makes surgeon's job accessible and increases the success rate of the operation. AM provides a perfect fit implant for the specific patient by unlimited geometric freedom. Various scanning technologies capture the status of bone defects, and printing of the model is done with the help of this technology. It gives an exact generation of a physical model which is also helpful for medical education, surgical planning and training. This technology can help to solve present-day challenges as data of every patient is different from another.

      Keywords

      1. Introduction

      In recent years, there has been a significant improvement in additive manufacturing technologies, and researchers have explored its applications in various fields of engineering and medicine. It creates a physical model from the digital 3D model without any requirement of process planning, physical tools and dies. This technology has great capability to fabricate complex shape prototypes with a variety of materials such as nylon, polymers and even metals. It produces implants of biocompatible materials that meet structural requirements.
      • Javaid M.
      • Haleem A.
      Additive manufacturing applications in medical cases: a literature-based review.
      Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003
      ,
      • Negi S.
      • Dhiman S.
      • Sharma R.K.
      Basics and applications of rapid prototyping medical models.
      Rapid Prototyp J. 2014; 20: 256-267
      Additive manufacturing is a type of manufacturing technology in which materials like powder, plastic or metal are deposited layer by layer to fabricate the 3D model from Computer Aided Design (CAD) model. This method is different from traditional manufacturing technology because rather than removing of material; it adds materials layer by layer. In surgical applications, this technology is used to create a model which gives a better understanding of complex pathology and anatomy of the patient. It easily produces specific custom implants and patient-specific instruments which help surgeon during the surgery of the patient.
      • Choi J.W.
      • Kim N.
      Erratum: clinical application of three-dimensional printing technology in craniofacial plastic surgery.
      Arch Plast Surg. 2015; 42: 513
      ,
      • Kumar L.
      • Tanveer Q.
      • Kumar V.
      • Javaid M.
      • Haleem A.
      Developing low cost 3D printer.
      Int J Appl Sci Eng Res. 2016; 5: 433-447
      In biomedical engineering, orthopaedics is surgical discipline applied through various disciplines such as joint arthroplasty, ranging from trauma surgery to tumour surgery for correction of the deformity. Orthopaedic applications provide a detailed analysis of the musculoskeletal system and craniomaxillofacial surgery.
      • Hoang D.
      • Perrault D.
      • Stevanovic M.
      • Ghiassi A.
      Surgical applications of three-dimensional printing: a review of the current literature & how to get started.
      Ann Transl Med. 2016; 4: 1-19
      ,
      • Javaid M.
      • Haleem A.
      Additive manufacturing applications in medical cases: a literature-based review.
      Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003
      Applications of additive manufacturing give a flexible solution with quick and cost-effective production of implants and also surgical instruments with high-quality of patient-specific. AM offers multiple benefits as compared to conventional implant production methods. By 3D CAD data, patient-specific parts are produced without using any tool along with required medically compatible materials and with a high quality of accuracy and precision. It makes surgeon job easier and optimise patient's treatment with minimum unpleasant side effects. AM methods can produce individual instrument and easily manufacture various medical devices. This technology is recasting in orthopaedic care that rapidly fabricates implantable devices by the use of bioactive materials and polymer.
      • Wong K.C.
      3D-printed patient-specific applications in orthopaedics.
      Orthop Res Rev. 2016; 8: 57-66
      ,
      • Negi S.
      • Dhiman S.
      • Sharma R.K.
      Basics and applications of rapid prototyping medical models.
      Rapid Prototyp J. 2014; 20: 256-267
      In orthopaedics, AM has extensive benefit for bone ingrowths capabilities. It enables to fabricate complex metal parts of the different shape, size and design. Regarding improving lives, it has a dramatic effect on the human condition. This is helpful for both clinical environment and manufacturing method. It creates implant of spinal devices, standard knee and helpful in the development of orthopaedic implant.
      • Wong K.C.
      3D-printed patient-specific applications in orthopaedics.
      Orthop Res Rev. 2016; 8: 57-66
      ,
      • Wong T.M.
      • Jin J.
      • Lau T.W.
      • Fang C.
      • Yan C.H.
      • Yeung K.
      • To M.
      • Leung F.
      The use of three-dimensional printing technology in orthopaedic surgery: a review.
      J Orthop Surg. 2017; 25: 1-7

      2. Generation of 3D objects by using additive manufacturing applications in orthopaedics

      In orthopaedic the patient-specific analysis is essential to obtain an accurate medical imaging data of the individual patient. Magnetic resonance imaging (MRI), modern multi-row detector Computer Tomography (MDCT), Computer tomography (CT) scan, X-rays and 3D scanners provide an accurate, fast, high-resolution data and easily prepare a 3D view of patient's anatomy. AM convert the digital medical image into a 3D physical model. This conversion takes place in three steps discussed in Table 1.
      Table 1Generation of 3D objects by using additive manufacturing applications.
      S NoSteps usedDescriptionReferences
      1Image acquisition
      • •
        High-quality medical image with high resolution in 3D virtual form is generated from various scanning technologies
      • •
        Image acquisition is the most critical step because physical model accuracy depends on this
      • •
        CT, MRI and 3D scanners are mainly used to capture the image for this purpose
      		Wong
      • Wong K.C.
      3D-printed patient-specific applications in orthopaedics.
      Orthop Res Rev. 2016; 8: 57-66
      ; Souzaki et al
      • Souzaki R.
      • Kinoshita Y.
      • Ieiri S.
      • Hayashida M.
      • Koga Y.
      • Shirabe K.
      • Hara T.
      • Maehara Y.
      • Hashizume M.
      • Taguchi T.
      Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child.
      Pediatr Surg Int. 2015; 31: 593-596
      ; Verma et al
      • Verma T.
      • Sharma A.
      • Sharma A.
      • Maini L.
      Customized iliac prosthesis for reconstruction in giant cell tumour: a unique treatment approach.
      J Clin Orthop Trauma. 2016; https://doi.org/10.1016/j.jcot.2016.10.001
      ; Lal et al
      • Lal H.
      • Kumar L.
      • Kumar R.
      • Boruah T.
      • Jindal P.K.
      • Sabharwal V.K.
      Inserting pedicle screws in lumbar spondylolisthesis – the easy bone conserving way.
      J Clin Orthop Trauma. 2017; https://doi.org/10.1016/j.jcot.2016.11.010
      2Image post-processing
      • •
        DICOM (Digital Imaging and Communications in Medicine) images are extracted for data reconstruction by the use of image post-processing software
      • •
        It is useful for examining skeletal structures and detailed information about joint alignment and fractures
      • •
        CAD software transforms the 3D model into a series of polygons and converts data into standard triangulate language (STL) format
      • •
        The input to the 3D printing machine for part fabrication, the data file is in STL format
      • •
        DICOM images also play an important role in medical imaging data for the specific patient and 3D printing technology
      		Jardini et al
      • Jardini A.L.
      • Larosa M.A.
      • Maciel Filho R.
      • CarvalhoZavaglia C.A.D.
      • Bernardes L.F.
      • Lambert C.S.
      • Calderoni D.R.
      • Kharmandayan P.
      Cranial reconstruction: 3D bio model and custom-built implant created using additive manufacturing.
      J Craniomaxillofac Surg. 2014; 42: 1877-1884
      ; Trace et al
      • Trace A.P.
      • Ortiz D.
      • Deal A.
      • Retrouvey M.
      • Elzie C.
      • Goodmurphy C.
      • Morey J.
      • Hawkins C.M.
      Radiology’s emerging role in 3-D printing applications in health care.
      J Am Coll Radiol. 2016; 13: 856-862
      33D printing
      • •
        CAD software divides the 3D model into "very thin" cross-sectional layers
      • •
        Additive manufacturing technologies fabricate 3D physical model by adding material layer by layer
      		Javaid and Haleem
      • Javaid M.
      • Haleem A.
      Additive manufacturing applications in medical cases: a literature-based review.
      Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003
      ; Martelli et al
      • Martelli N.
      • Serrano C.
      • van den Brink H.
      • Pineau J.
      • Prognon P.
      • Borget I.
      • El Batti S.
      Advantages and disadvantages of 3-dimensional printing in surgery: a systematic review.
      Surgery. 2016; 159: 1485-1500
      The data is captured by advanced medical imaging, making the diagnosis reliable and more manageable.
      • Vaishyaa R.
      • Vijaya V.
      • Krishnan B.M.
      • Agarwala A.K.
      Fallacies of CT based component size prediction in total knee arthroplasty – are patient-specific instruments the answer?.
      J Clin Orthop Trauma. 2017; https://doi.org/10.1016/j.jcot.2017.11.001
      ,
      • Srivastava A.
      • Aggarwal A.N.
      • Mishra P.
      • Bhateja D.
      Femoral fracture acting as an “ominous masquerade’’ in a 7-year-old child.
      J Clin Orthop Trauma. 2016; 7: 27-29
      3-D reconstruction images from these scanning technologies provide superior visualisation. This provides better surgical management and accurate diagnosis. These scanning technologies give 3D pictures displayed on a computer screen which cannot affect the perception of a physical model for complicated cases. For this, it is necessary to print these 3D models by the additive manufacturing technologies for the complete understanding. These 3D printed models provide better information to the surgeon. Before printing it is necessary to prepare DICOM which is extracted from the medical imaging and then convert it into STL format to complete the printing process by 3D printing machines.
      • Javaid M.
      • Haleem A.
      Additive manufacturing applications in medical cases: a literature-based review.
      Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003

      3. Applications of additive manufacturing in orthopaedics

      Additive manufacturing provides tremendous development in manufacturing field and now explore its applications in various medical fields. The 3D printed model's first goal is to resemble the cases in the clinic and give a detailed overview to the surgeon. The principal application of this model is for the testing procedure in advance as it provides a feeling of the mechanical response of real bone to the surgeon. The operation can also be performed on the 3D model to examine and visualise before performing actual surgery. Table 2 describes various applications of additive manufacturing in orthopaedics.
      Table 2Applications of Additive Manufacturing in Orthopaedics.
      S NoApplicationsDescriptionReferences
      1Anatomic models for the planning of surgery
      • •
        Traditionally the preoperative planning by an orthopaedic surgeon is done with the help of 2D Plain CT images and X-ray to assess the pathology and bony anatomy of the patient
      • •
        By the application of AM advanced image post-processing software is used to produce 3D images and 3D non-axial reformatted images
      • •
        The 3D anatomy can be viewed, and patient-specific physical bone models can be regenerated from patient's 3D data by using additive manufacturing technologies
      • •
        This physical model can help surgeons to have a visual and tactile understanding of the patient-specific pathology and anatomy
      		Pacione et al
      • Pacione D.
      • Tanweer O.
      • Berman P.
      • Harter D.H.
      The utility of a multi-material 3D printed model for surgical planning of complex deformity of the skull base and craniovertebral junction.
      J Neurosurg. 2016; 125: 1194-1197
      ; Vaish and Vaish
      • Vaish A.
      • Vaish R.
      3D printing and its applications in orthopedics.
      J Clin Orthop Trauma. 2018; https://doi.org/10.1016/j.jcot.2018.02.003
      ; Pietrabissa et al
      • Pietrabissa A.
      • Marconi S.
      • Peri A.
      • Pugliese L.
      • Cavazzi E.
      • Vinci A.
      • Botti M.
      • Auricchio F.
      From CT scanning to 3D printing technology for the preoperative planning in laparoscopic splenectomy.
      Surg Endosc. 2016; 30: 366-371
      ; Souzaki et al
      • Souzaki R.
      • Kinoshita Y.
      • Ieiri S.
      • Hayashida M.
      • Koga Y.
      • Shirabe K.
      • Hara T.
      • Maehara Y.
      • Hashizume M.
      • Taguchi T.
      Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child.
      Pediatr Surg Int. 2015; 31: 593-596
      2Cost-effectiveness for orthopaedics
      • •
        Traditionally there are standardised instruments that are not useful for every patient
      • •
        AM produced higher productivity customised implants and instruments at a lower cost as compared to the conventionally manufactured system
      • •
        The surgeon can easily achieve high-quality product to meet the required standard in orthopaedics
      • •
        It is a cost-effective tool for the hospital which fulfils the customised requirement of the surgeon
      		Trace et al
      • Trace A.P.
      • Ortiz D.
      • Deal A.
      • Retrouvey M.
      • Elzie C.
      • Goodmurphy C.
      • Morey J.
      • Hawkins C.M.
      Radiology’s emerging role in 3-D printing applications in health care.
      J Am Coll Radiol. 2016; 13: 856-862
      ; Salmi et al
      • Salmi M.
      • Tuomi J.
      • Paloheimo K.S.
      • Björkstrand R.
      • Paloheimo M.
      • Salo J.
      • Kontio R.
      • Mesimäki K.
      • Mäkitie A.A.
      Patient-specific reconstruction with 3D modeling and DMLS additive manufacturing.
      Rapid Prototyp J. 2012; 18: 209-214
      ; Javaid et al
      • Javaid M.
      • Kumar L.
      • Kumar V.
      • Haleem A.
      Product design and development using polyjet rapid prototyping technology.
      Control Theor Inf. 2015; 5: 12-19
      ; Kumar et al
      • Kumar L.
      • Tanveer Q.
      • Kumar V.
      • Javaid M.
      • Haleem A.
      Developing low cost 3D printer.
      Int J Appl Sci Eng Res. 2016; 5: 433-447
      3Surgical guides
      • •
        AM is applied successfully for the fabrication of patient-specific surgical guides and implants
      • •
        It is used for a tumour, total joint arthroplasty and deformity correction
      • •
        It helps surgeons for the designing of surgical cutting guides which perfectly match the anatomy of the patient with reasonable accuracy
      • •
        For synthetic devices and individually printed implants, this technology is used efficiently for even complicated cases such as a spinal tumour and pelvic tumour
      • •
        By the applications of this technology, surgical tools can also be redesigned and manufactured
      		Yap et al
      • Yap Y.L.
      • Tan Y.S.E.
      • Tan H.K.J.
      • Peh Z.K.
      • Low X.Y.
      • Yeong W.Y.
      • Tan C.S.H.
      • Laude A.
      3D printed bio-models for medical applications.
      Rapid Prototyp J. 2017; 23: 227-235
      ; Wong et al
      • Wong K.C.
      • Kumta S.M.
      • Geel N.V.
      • Demol J.
      One-step reconstruction with a 3D-printed, biomechanically evaluated custom implant after complex pelvic tumor resection.
      Comput Aided Surg. 2015; 20: 14-23
      ; Javaid and Haleem
      • Javaid M.
      • Haleem A.
      Additive manufacturing applications in medical cases: a literature-based review.
      Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003
      4Patient-specific instruments
      • •
        Patient-specific instruments are made by the bony anatomy of the 3D surface model
      • •
        It is created from image segmentation of a patient which is easily fabricated by AM technologies for orthopaedic applications
      • •
        Used for easy replication of surgical plans which involve for drill in a specific planned direction and guiding a saw
      • •
        Helps for performing difficult osteotomies and guide accurate implant placement of the knee
      • •
        For oncological clearance, this technology helps to improve the bone resection accuracy and aids in bone tumour surgery
      		Trace et al
      • Trace A.P.
      • Ortiz D.
      • Deal A.
      • Retrouvey M.
      • Elzie C.
      • Goodmurphy C.
      • Morey J.
      • Hawkins C.M.
      Radiology’s emerging role in 3-D printing applications in health care.
      J Am Coll Radiol. 2016; 13: 856-862
      ; Negi et al
      • Negi S.
      • Dhiman S.
      • Sharma R.K.
      Basics and applications of rapid prototyping medical models.
      Rapid Prototyp J. 2014; 20: 256-267
      ; Han et al
      • Han Q.
      • Qin Y.
      • Zou Y.
      • Wang C.
      • Bai H.
      • Yu T.
      • Huang L.
      • Wang J.
      Novel exploration of 3D printed wrist arthroplasty to solve the severe and complicated bone defect of wrist.
      Rapid Prototyp J. 2017; 23: 465-473
      5Bone tissue engineering
      • •
        It is an interdisciplinary field which combines biomaterials, cell and biochemical factors to regenerate a new bone
      • •
        Currently, structurally sophisticated bioscaffolds production is done by AM technology
      • •
        To achieve mechanical and biological properties 3-D bioscaffolds is designed as per the requirement of the clinical application
      		Zein et al
      • Zein I.
      • Hutmacher D.W.
      • Tan K.C.
      • Teoh S.H.
      Fused deposition modeling of novel scaffold architectures for tissue engineering applications.
      Biomaterials. 2002; 23: 1169-1185
      ; Peltola et al
      • Peltola S.M.
      • Melchels F.P.
      • Grijpma D.W.
      • Kellomäki M.
      A review of rapid prototyping techniques for tissue engineering purposes.
      Ann Med. 2008; 40: 268-280
      63D-printed custom implants
      • •
        Traditional manufacturing methods are used to fabricate standard-sized bone implants and fulfil the surgical requirement for most of the patients, but they do not accurately fit, and there is a level of discomfort and poor functionality
      • •
        AM technology create a 3D bone implant from patient's medical image with perfect match that fulfils the requirement
      • •
        Improves the surgical results which give perfect fit of patient anatomical and medical implant requirement
      		Jardini et al
      • Jardini A.L.
      • Larosa M.A.
      • Maciel Filho R.
      • CarvalhoZavaglia C.A.D.
      • Bernardes L.F.
      • Lambert C.S.
      • Calderoni D.R.
      • Kharmandayan P.
      Cranial reconstruction: 3D bio model and custom-built implant created using additive manufacturing.
      J Craniomaxillofac Surg. 2014; 42: 1877-1884
      ; Wong et al
      • Wong T.M.
      • Jin J.
      • Lau T.W.
      • Fang C.
      • Yan C.H.
      • Yeung K.
      • To M.
      • Leung F.
      The use of three-dimensional printing technology in orthopaedic surgery: a review.
      J Orthop Surg. 2017; 25: 1-7
      7Bone Defect
      • •
        3D scanning technologies are easily used to capture bone defects which are converted into 3D virtual model form and import to additive manufacturing technologies for build 3D physical model
      • •
        From this model, the surgeon can easily see the status of defect or damaged bone
      • •
        Help surgeon to complete surgery precisely and successfully
      		Han et al
      • Han Q.
      • Qin Y.
      • Zou Y.
      • Wang C.
      • Bai H.
      • Yu T.
      • Huang L.
      • Wang J.
      Novel exploration of 3D printed wrist arthroplasty to solve the severe and complicated bone defect of wrist.
      Rapid Prototyp J. 2017; 23: 465-473
      ; Pietrabissa et al
      • Pietrabissa A.
      • Marconi S.
      • Peri A.
      • Pugliese L.
      • Cavazzi E.
      • Vinci A.
      • Botti M.
      • Auricchio F.
      From CT scanning to 3D printing technology for the preoperative planning in laparoscopic splenectomy.
      Surg Endosc. 2016; 30: 366-371
      8Improved patient care
      • •
        For specific patient AM produced an implant more precisely that reduces the risk of the operation
      • •
        The operation can perform with a minimal invasion that lessens the overall stress of the patient
      		Salmi et al
      • Salmi M.
      • Tuomi J.
      • Paloheimo K.S.
      • Björkstrand R.
      • Paloheimo M.
      • Salo J.
      • Kontio R.
      • Mesimäki K.
      • Mäkitie A.A.
      Patient-specific reconstruction with 3D modeling and DMLS additive manufacturing.
      Rapid Prototyp J. 2012; 18: 209-214
      ; Boonen et al
      • Boonen B.
      • Schotanus M.G.
      • Kort N.P.
      Preliminary experience with the patient-specific templating total knee arthroplasty.
      Acta Orthop. 2012; 83: 387-393
      9Precision for surgeons
      • •
        The operation performed by various surgical instruments manufactured by additive manufacturing technologies is easier for the surgeon
      • •
        The design can be optimised, and its functionality can be enhanced
      		Yap et al
      • Yap Y.L.
      • Tan Y.S.E.
      • Tan H.K.J.
      • Peh Z.K.
      • Low X.Y.
      • Yeong W.Y.
      • Tan C.S.H.
      • Laude A.
      3D printed bio-models for medical applications.
      Rapid Prototyp J. 2017; 23: 227-235
      ; Choi and Kim
      • Choi J.W.
      • Kim N.
      Erratum: clinical application of three-dimensional printing technology in craniofacial plastic surgery.
      Arch Plast Surg. 2015; 42: 513
      10Weight reduction of implants
      • •
        Manufacture implants which have less weight
      • •
        This technology has exceptional tendency to reduce the weight of the implant by changing properties of the raw material
      • •
        Due to freedom of design, it produces complex geometry implant with optimum weight
      • •
        By reduction in weight of implant, the patient feels comfortable
      		Wang et al
      • Wang Y.T.
      • Yang X.J.
      • Yan B.
      • Zeng T.H.
      • Qiu Y.Y.
      • Chen S.S.
      Clinical application of three-dimensional printing in the personalized treatment of complex spinal disorders.
      Chin J Traumatol. 2016; 19: 31-34
      ; Peltola et al
      • Peltola S.M.
      • Melchels F.P.
      • Grijpma D.W.
      • Kellomäki M.
      A review of rapid prototyping techniques for tissue engineering purposes.
      Ann Med. 2008; 40: 268-280
      11Osteochondral and Chondral defect
      • •
        AM is helpful for Osteochondral and Chondral defects
      • •
        The volume of these defects is also examined through the applications of this technology and helps to solve the problem of these type of defects during operation
      		Boonen et al
      • Boonen B.
      • Schotanus M.G.
      • Kort N.P.
      Preliminary experience with the patient-specific templating total knee arthroplasty.
      Acta Orthop. 2012; 83: 387-393
      ; Pacione et al
      • Pacione D.
      • Tanweer O.
      • Berman P.
      • Harter D.H.
      The utility of a multi-material 3D printed model for surgical planning of complex deformity of the skull base and craniovertebral junction.
      J Neurosurg. 2016; 125: 1194-1197
      12Education and surgical training
      • •
        3D-printed patient-specific models can be used for preoperative discussions and education about strategies
      • •
        The application of the 3D printed model has been used for Blount disease, Perthe's disease, physical bars or coalitions
      • •
        It also assists therapists, surgeons, and patients for a better the understanding of patient's musculoskeletal pathology
      • •
        Families of the patient can understand better about medical conditions of a patient with real physical models printed by additive manufacturing technologies
      • •
        Increase the patient satisfaction and safety
      • •
        3D model can be used to train doctor and medical students for better understanding of the various types of fractures
      • •
        Helps the surgeon to practice on prototype printed by this technique and more familiar with patient-specific scenarios
      		Mahmoud et al
      • Mahmoud A.
      • Bennett M.
      Introducing 3-dimensional printing of a human anatomic pathology specimen: potential benefits for undergraduate and postgraduate education and anatomic pathology practice.
      Arch Pathol Lab Med. 2015; 139: 1048-1051
      ; Sodian et al
      • Sodian R.
      • Weber S.
      • Markert M.
      • Loeff M.
      • Lueth T.
      • Weis F.C.
      • Daebritz S.
      • Malec E.
      • Schmitz C.
      • Reichart B.
      Pediatric cardiac transplantation: three-dimensional printing of anatomic models for surgical planning of heart transplantation in patients with univentricular heart.
      J Thorac Cardiovasc Surg. 2008; 136: 1098-1099
      ; Hurson et al
      • Hurson C.
      • Tansey A.
      • O’Donnchadha B.
      • Nicholson P.
      • Rice J.
      • McElwain J.
      Rapid prototyping in the assessment, classification and pre-operative planning of acetabular fractures.
      Injury. 2007; 38: 1158-1162
      The applications of additive manufacturing in orthopaedic surgery provide reproducible, safe and reliable models that improve patient outcomes and reduced operating time as compared to traditional surgical techniques. This technology can work successfully for preoperative planning, education and custom manufacturing. For Custom manufacturing applications it is used for prosthetics, surgical guides and implants. 3D printed models of anatomy have assisted in the education of students, trainees, patients and surgeons. Surgeon and doctors can use 3D printed bone model for practising of surgery and explain the patient or students about the surgery. It also has potential to increase the number of tools for the surgeon and easily undertake the redesigning. It becomes a valuable tool that has an impact on every area of medicine. Surgeons can now develop new tools and techniques for surgical procedures.

      4. Discussion

      Additive manufacturing easily develops personalised prostheses and implants which is more valuable in the field of orthopaedics. This technology can rapidly fabricate implants of any desired shape and also used for the production of size-controllable micro-pore structures. For research and development of orthopaedic implants, it is promising. Its applications are enhanced in medical and solve various problems regarding this field. 3D printed physical model can help surgeons to have a visual and tactile understanding of the patient-specific pathology and anatomy. Surgeon and patient can now understand easily about the medical conditions with a real 3D physical model. It increases the patient satisfaction and safety. It is helpful to give training to the doctor and medical students for better understanding of the various types of fractures. Customised and high-quality implants with a wide variety of material are quickly built to meet the required standard in orthopaedics with minimum risk. By changing the properties of the raw material, this technology tends to reduce the weight of the implant. It gives a flexible solution with the quick and cost-effective production of various medical tools and devices.

      5. Limitations and future scope

      The cost of additive manufacturing technology is very high that includes software, hardware, skilled human resources for operating, maintaining as well as the cost of printing materials. AM creates implants with high cost and also required a high cost of designing. Another limitation of this technology is the timescale physical model production. It is variable that depends on the complexity and size of the model. Image acquisition and data processing take time. Then for the fabrication of model, it depends on the types of technologies of additive manufacturing. The machines take 24 h to complete the printing process of the standard model. Model printed by this technology has limited application. In some cases, it is not implemented and can only be used for a better understanding of the actual surgery. In orthopaedics, implants printed by AM technology are fabricated layer by layer and bonded together. Sometimes mechanical strength that the user required is not achieved and thus makes it unsuitable for long-term use.
      In future, 3D-printed custom implants can be a suitable adjunct for the patients. Artificial bone consist mechanical properties that are similar to human bone. It opens a reconstruction option that helps orthopaedic surgeons, radiologists, and implant companies. By using this technology surgeon take help to facilitate customised patient treatments of their patients. It presents new opportunities in orthopaedics for exact generation of the physical model which is also suitable for education, surgical planning and training. This technology can solve present-day challenges in medical because, in medical, the data of every patient is different from each other. Among different care providers, it provides seamless communications. This can give elastic properties and strength close to the actual bone. It produced the implant of required shape and size before the actual surgery that improves quality of surgery of the patient. It helps to impart an enhanced long-term quality of life of the patient.

      6. Conclusion

      Additive manufacturing is a type of manufacturing process that produces a 3D object from the digital model. Based on CT and MRI, the bone 3D image can be reconstructed, and then obtains a bone prototype by layer by layer technique and play an effective role in medical as well as in orthopaedic surgery. This is helpful for surgical design, teaching and presentation of complex surgeries. By using reverse engineering technique of AM, a missing part of the bone is created. The popularity and advancement of this technology are for implant design and fabrication, tissue engineering, preoperative surgical planning and even in training of doctors and surgeon. It produces an implant of the individual patient at a fast pace which fits better as compared to standard implant manufacturing by the traditional manufacturing process. The true physical model produced by this technology allows the surgeon to have a better understanding. Production of scaffolds for bone tissue engineering is another application of this technology which is used for the fabrication of structurally sophisticated bio-scaffolds. 3-D bio-scaffolds are designed as per the need of clinical applications with significant mechanical and biological properties. 3D printed surgical guides simplify the surgery that reduces operative time and makes surgery precise. CT and MRI scan are used to capture data, and additive manufacturing technologies are used to make surgery successful.

      Conflict of interest

      None.

      References

        • Javaid M.
        • Haleem A.
        Additive manufacturing applications in medical cases: a literature-based review.
        Alex J Med. 2017; https://doi.org/10.1016/j.ajme.2017.09.003
        View in Article
        • Negi S.
        • Dhiman S.
        • Sharma R.K.
        Basics and applications of rapid prototyping medical models.
        Rapid Prototyp J. 2014; 20: 256-267
        View in Article
        • Choi J.W.
        • Kim N.
        Erratum: clinical application of three-dimensional printing technology in craniofacial plastic surgery.
        Arch Plast Surg. 2015; 42: 513
        View in Article
        • Kumar L.
        • Tanveer Q.
        • Kumar V.
        • Javaid M.
        • Haleem A.
        Developing low cost 3D printer.
        Int J Appl Sci Eng Res. 2016; 5: 433-447
        View in Article
        • Hoang D.
        • Perrault D.
        • Stevanovic M.
        • Ghiassi A.
        Surgical applications of three-dimensional printing: a review of the current literature & how to get started.
        Ann Transl Med. 2016; 4: 1-19
        View in Article
        • Wong K.C.
        3D-printed patient-specific applications in orthopaedics.
        Orthop Res Rev. 2016; 8: 57-66
        View in Article
        • Wong T.M.
        • Jin J.
        • Lau T.W.
        • Fang C.
        • Yan C.H.
        • Yeung K.
        • To M.
        • Leung F.
        The use of three-dimensional printing technology in orthopaedic surgery: a review.
        J Orthop Surg. 2017; 25: 1-7
        View in Article
        • Souzaki R.
        • Kinoshita Y.
        • Ieiri S.
        • Hayashida M.
        • Koga Y.
        • Shirabe K.
        • Hara T.
        • Maehara Y.
        • Hashizume M.
        • Taguchi T.
        Three-dimensional liver model based on preoperative CT images as a tool to assist in surgical planning for hepatoblastoma in a child.
        Pediatr Surg Int. 2015; 31: 593-596
        View in Article
        • Verma T.
        • Sharma A.
        • Sharma A.
        • Maini L.
        Customized iliac prosthesis for reconstruction in giant cell tumour: a unique treatment approach.
        J Clin Orthop Trauma. 2016; https://doi.org/10.1016/j.jcot.2016.10.001
        View in Article
        • Lal H.
        • Kumar L.
        • Kumar R.
        • Boruah T.
        • Jindal P.K.
        • Sabharwal V.K.
        Inserting pedicle screws in lumbar spondylolisthesis – the easy bone conserving way.
        J Clin Orthop Trauma. 2017; https://doi.org/10.1016/j.jcot.2016.11.010
        View in Article
        • Jardini A.L.
        • Larosa M.A.
        • Maciel Filho R.
        • CarvalhoZavaglia C.A.D.
        • Bernardes L.F.
        • Lambert C.S.
        • Calderoni D.R.
        • Kharmandayan P.
        Cranial reconstruction: 3D bio model and custom-built implant created using additive manufacturing.
        J Craniomaxillofac Surg. 2014; 42: 1877-1884
        View in Article
        • Trace A.P.
        • Ortiz D.
        • Deal A.
        • Retrouvey M.
        • Elzie C.
        • Goodmurphy C.
        • Morey J.
        • Hawkins C.M.
        Radiology’s emerging role in 3-D printing applications in health care.
        J Am Coll Radiol. 2016; 13: 856-862
        View in Article
        • Martelli N.
        • Serrano C.
        • van den Brink H.
        • Pineau J.
        • Prognon P.
        • Borget I.
        • El Batti S.
        Advantages and disadvantages of 3-dimensional printing in surgery: a systematic review.
        Surgery. 2016; 159: 1485-1500
        View in Article
        • Vaishyaa R.
        • Vijaya V.
        • Krishnan B.M.
        • Agarwala A.K.
        Fallacies of CT based component size prediction in total knee arthroplasty – are patient-specific instruments the answer?.
        J Clin Orthop Trauma. 2017; https://doi.org/10.1016/j.jcot.2017.11.001
        View in Article
        • Srivastava A.
        • Aggarwal A.N.
        • Mishra P.
        • Bhateja D.
        Femoral fracture acting as an “ominous masquerade’’ in a 7-year-old child.
        J Clin Orthop Trauma. 2016; 7: 27-29
        View in Article
        • Pacione D.
        • Tanweer O.
        • Berman P.
        • Harter D.H.
        The utility of a multi-material 3D printed model for surgical planning of complex deformity of the skull base and craniovertebral junction.
        J Neurosurg. 2016; 125: 1194-1197
        View in Article
        • Vaish A.
        • Vaish R.
        3D printing and its applications in orthopedics.
        J Clin Orthop Trauma. 2018; https://doi.org/10.1016/j.jcot.2018.02.003
        View in Article
        • Pietrabissa A.
        • Marconi S.
        • Peri A.
        • Pugliese L.
        • Cavazzi E.
        • Vinci A.
        • Botti M.
        • Auricchio F.
        From CT scanning to 3D printing technology for the preoperative planning in laparoscopic splenectomy.
        Surg Endosc. 2016; 30: 366-371
        View in Article
        • Salmi M.
        • Tuomi J.
        • Paloheimo K.S.
        • Björkstrand R.
        • Paloheimo M.
        • Salo J.
        • Kontio R.
        • Mesimäki K.
        • Mäkitie A.A.
        Patient-specific reconstruction with 3D modeling and DMLS additive manufacturing.
        Rapid Prototyp J. 2012; 18: 209-214
        View in Article
        • Javaid M.
        • Kumar L.
        • Kumar V.
        • Haleem A.
        Product design and development using polyjet rapid prototyping technology.
        Control Theor Inf. 2015; 5: 12-19
        View in Article
        • Yap Y.L.
        • Tan Y.S.E.
        • Tan H.K.J.
        • Peh Z.K.
        • Low X.Y.
        • Yeong W.Y.
        • Tan C.S.H.
        • Laude A.
        3D printed bio-models for medical applications.
        Rapid Prototyp J. 2017; 23: 227-235
        View in Article
        • Wong K.C.
        • Kumta S.M.
        • Geel N.V.
        • Demol J.
        One-step reconstruction with a 3D-printed, biomechanically evaluated custom implant after complex pelvic tumor resection.
        Comput Aided Surg. 2015; 20: 14-23
        View in Article
        • Han Q.
        • Qin Y.
        • Zou Y.
        • Wang C.
        • Bai H.
        • Yu T.
        • Huang L.
        • Wang J.
        Novel exploration of 3D printed wrist arthroplasty to solve the severe and complicated bone defect of wrist.
        Rapid Prototyp J. 2017; 23: 465-473
        View in Article
        • Zein I.
        • Hutmacher D.W.
        • Tan K.C.
        • Teoh S.H.
        Fused deposition modeling of novel scaffold architectures for tissue engineering applications.
        Biomaterials. 2002; 23: 1169-1185
        View in Article
        • Peltola S.M.
        • Melchels F.P.
        • Grijpma D.W.
        • Kellomäki M.
        A review of rapid prototyping techniques for tissue engineering purposes.
        Ann Med. 2008; 40: 268-280
        View in Article
        • Boonen B.
        • Schotanus M.G.
        • Kort N.P.
        Preliminary experience with the patient-specific templating total knee arthroplasty.
        Acta Orthop. 2012; 83: 387-393
        View in Article
        • Wang Y.T.
        • Yang X.J.
        • Yan B.
        • Zeng T.H.
        • Qiu Y.Y.
        • Chen S.S.
        Clinical application of three-dimensional printing in the personalized treatment of complex spinal disorders.
        Chin J Traumatol. 2016; 19: 31-34
        View in Article
        • Mahmoud A.
        • Bennett M.
        Introducing 3-dimensional printing of a human anatomic pathology specimen: potential benefits for undergraduate and postgraduate education and anatomic pathology practice.
        Arch Pathol Lab Med. 2015; 139: 1048-1051
        View in Article
        • Sodian R.
        • Weber S.
        • Markert M.
        • Loeff M.
        • Lueth T.
        • Weis F.C.
        • Daebritz S.
        • Malec E.
        • Schmitz C.
        • Reichart B.
        Pediatric cardiac transplantation: three-dimensional printing of anatomic models for surgical planning of heart transplantation in patients with univentricular heart.
        J Thorac Cardiovasc Surg. 2008; 136: 1098-1099
        View in Article
        • Hurson C.
        • Tansey A.
        • O’Donnchadha B.
        • Nicholson P.
        • Rice J.
        • McElwain J.
        Rapid prototyping in the assessment, classification and pre-operative planning of acetabular fractures.
        Injury. 2007; 38: 1158-1162
        View in Article

      Article info

      Publication history

      Published online: April 23, 2018
      Accepted: April 17, 2018
      Received in revised form: April 9, 2018
      Received: February 20, 2018

      Identification

      DOI: https://doi.org/10.1016/j.jcot.2018.04.008

      Copyright

      © 2018 Delhi Orthopedic Association. All rights reserved.

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