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Morton’s neuroma is a common pathology affecting the forefoot. It is not a true neuroma but is fibrosis of the nerve. This is caused secondary to pressure or repetitive irritation leading to thickness of the digital nerve, located in the third or second intermetatarsal space. The treatment options are: orthotics, steroid injections and surgical excision usually performed through dorsal approach. Careful clinical examination, patient selection, pre-operative counselling and surgical technique are the key to success in the management of this condition.
Morton’s neuroma was first described in the literature in 1876 by an American surgeon, Thomas George Morton. It is a common pathology affecting the forefoot. It is not a true neuroma but is fibrosis of the digital nerve. This is caused secondary to pressure or repetitive irritation leading to thickness of the nerve, located in the second or third intermetatarsal space. The third intermetatarsal space is most commonly affected. Histologically the neuroma has neural oedema, demyelination (axonal injury) and perineural fibrosis.
This degenerate tissue therefore causes localised pain and discomfort mainly on weight bearing. Current literature suggests that the use of pointed heeled shoes may be a causative factor because this increase in pressure over the forefoot can lead to neuronal injury.
The classical description of a Morton’s neuroma is paraesthesia within the affected digital nerve, accompanied by forefoot pain and is more commonly seen in females. 17% of patients describe some trauma to the foot resulting in symptoms.
The most common characteristic of the pain is burning in nature. Altered sensations and feeling a “pebble in the shoe” is reported by more than 50% of patients. The pain is often exacerbated by walking, use of tight or heeled shoes and is reported by runners due to the increased weight bearing through the forefoot.
Resting the foot or removing the shoe improves pain in most cases especially early in the onset of this condition. In chronic cases the pain could be constant. Night pain and rest pain is reported by about 25% of patients.
Clinically, there are no visual cues to the presence of a neuroma. Any deformity of the foot specially hallux valgus can lead to overcrowding of the toes and increased pressure on the lesser toes, and is therefore an important predisposing factor. Plantar callosities around metatarsal heads are suggestive of transfer metatarsalgia, synovitis, subluxation or dislocation of metatarso-phalangeal joint of 2nd or 3rd toes. The other differential diagnoses include: plantar plate tear, Freiberg’s disease, stress response or stress fracture of metatarsals. It has been reported that clinical assessment by experienced clinician has up to 98% accuracy as compared to an ultrasound (USS) examination.
The most sensitive clinical tests for the diagnosis of Morton’s neuroma are the thumb index finger squeeze test, Mulder’s click test and foot squeeze test in that order. Thumb index finger test is performed by applying pressure in the intermetatarsal space. Thumb is placed on the dorsal aspect whereas index finger is kept on the plantar aspect. Positive test results in pain in presence of Morton’s neuroma. It is important to make sure that the pressure is exerted in the intermetatarsal space and not in the metatarsophalangeal joint itself. Splaying of toes is a good indication that the test has been performed appropriately.
Mulder’s click test is performed by dorsiflexing the foot and squeezing the metatarsals. An audible click is suggestive of presence of Morton’s neuroma. This test does not specify which intermetatarsal space which is affected. It is dependent on size of the neuroma and is usually positive in Morton’s neuroma measuring 1 cm or more.
A baseline weight bearing radiograph will aid in the exclusion of other causes of forefoot pain and give an overview of the osteology. USS and Magnetic Resonance imaging (MRI) are comparable modalities for diagnosing Morton’s neuroma.
An experienced musculoskeletal radiologist can elicit a neuroma with a sensitivity of 95% with USS (Fig. 1). However, if there is any doubt of the diagnosis, an MRI scan is the gold standard investigation to identify a neuroma, which can most easily be seen on T1 axial slice (Fig. 2).
The presence of a neuroma will not automatically cause the patient to experience the symptoms of a Morton’s neuroma. Bencardino reviewed 57 patients and noted that a third of the patients radiologically had a neuroma but were asymptomatic. The mean diameter was 4.1 mm in the asymptomatic group compared to 5.3 mm in the symptomatic group.
The diagnosis of Morton’s neuroma is relevant only when the transverse diameter on an MRI scan is 5 mm or more and can be correlated to clinical findings.
A prospective randomised controlled trial demonstrated no statistically significant difference in the mean size of neuromas that responded to treatment with steroid injections (11 mm), compared to those that did not (12.5 mm). Authors of the study also noted that the size of the neuroma was not significantly different in patients who had a recurrence of symptoms as compared to those who continued to be pain free at 12 months.
Makki D, Haddad BZ, Mahmood Z, Saleem Shahid M, Pathak S, Garnham I. Efficacy of Corticosteroid Injection Versus Size of Plantar Interdigital Neuroma Level of Evidence: II, Prospective Comparative Study. doi:10.3113/FAI.2012.0722.
The literature therefore suggests that size of the lesion does not always correlate with symptom severity, and although smaller neuromas will respond to steroid injections better than larger ones, patient reported outcome will improve for both with the injections.
6. Management
The management of neuroma can be split into non-operative measures or surgical management. The treatment algorithm, generally involves non-operative measures including injection therapy and if these methods fail to improve symptoms, surgical excision is the next option.
Patient education is very important and the use of wide toebox shoes can be the simplest method of managing symptoms. However, patient compliance is an issue and can result in failure to resolve symptoms.
7. Orthotics
The commonest form of treatment (initially) is the Metatarsal Bar. This insole, made by orthotists spreads the heads of the metatarsals to relieve pressure on the neuroma and thus improve symptoms. However, this does require the patient to wear broad toe box shoes and use the inserts so a degree of compliance is required. There is no evidence to support the use of inversion or eversion insoles, with studies demonstrating no significant improvement in patient reported outcomes.
Their use is therefore not recommended for the treatment of Morton’s Neuroma.
8. Injection therapy
The use of therapeutic injections is very common in the management of Morton’s neuroma, and multiple therapies have been used. The injection can be guided by USS or done using a landmark technique. A randomised trial by Mahadevan et al did not show any statistical difference in patient outcomes after a steroid injection using USS or without.
Santiago et al. noted that short term improvement in visual analogue scale (VAS) over 3 months in the group of patients having USS guided injections was better but the effect was not sustained at 6 months.
In a randomised controlled study comparing insoles with steroid injections, Saygi et al. reported that orthotics on their own were not very helpful. Their results suggested that 82% of patients who received 2–3 steroid injections reported complete satisfaction at 12 months.
Corticosteroid is currently the mainstay of injection treatment for Morton’s Neuroma. Outcomes for this modality show an improvement in multiple different patient reported outcome measures at 12 months.
Makki D, Haddad BZ, Mahmood Z, Saleem Shahid M, Pathak S, Garnham I. Efficacy of Corticosteroid Injection Versus Size of Plantar Interdigital Neuroma Level of Evidence: II, Prospective Comparative Study. doi:10.3113/FAI.2012.0722.
Markovic M, Bs M. Effectiveness of ultrasound-guided corticosteroid injection in the treatment of morton’s neuroma. Foot Ankle Int. doi:10.3113/FAI.2008.0483.
Although the mechanism of action is unclear as the neuroma is degenerate in nature, the understanding is that the steroid reduces the inflammation surrounding the neuroma and therefore reduces pain and also local pressure effects. In a randomised controlled trial, it has been shown that corticosteroid injections are more effective than local anaesthetic alone.
Makki D, Haddad BZ, Mahmood Z, Saleem Shahid M, Pathak S, Garnham I. Efficacy of Corticosteroid Injection Versus Size of Plantar Interdigital Neuroma Level of Evidence: II, Prospective Comparative Study. doi:10.3113/FAI.2012.0722.
Markovic M, Bs M. Effectiveness of ultrasound-guided corticosteroid injection in the treatment of morton’s neuroma. Foot Ankle Int. doi:10.3113/FAI.2008.0483.
Markovic M, Bs M. Effectiveness of ultrasound-guided corticosteroid injection in the treatment of morton’s neuroma. Foot Ankle Int. doi:10.3113/FAI.2008.0483.
There are a number of studies looking into the use of ethanol/alcohol injections into neuroma, which show improvement in patient reported outcome measures at 12 months and reduction in neuroma size.
Although the 12 month outcomes were promising with 84% patients reporting complete resolution of symptoms, at 5 years this was the case in only 29% of patients. In addition, a third of patients reported complications which include burning pain associated with alcohol injections which in some cases lasted for weeks.
Moreover, subsequent surgery following alcohol injections can be difficult due to increased fibrosis and for these reasons we do not recommend alcohol injections for the treatment of Morton’s neuroma.
Radiofrequency ablation is another treatment option which involves inserting a probe into the neuroma. The probe is then heated to between 85 and 90 °C. Although multiple studies report good patient reported outcomes, they have all been small, retrospective in design, with short term follow up. Radiofrequency ablation is not recommended as routine treatment by National Institute of Clinical Excellence (NICE).
Similarly, capsaicin, cryotherapy, Yttrium Aluminium Garnet (YAG) laser, extra-corporeal shockwave therapy and Botox injections have all been studied for the treatment of Morton’s neuroma. However, all were small studies with short term follow up, and only weak evidence for their use and are therefore not recommended by the authors.
The neuroma can be excised by two methods, either a dorsal or plantar approach. The dorsal approach allows the patient to weight bear immediately, with the plantar approach there is a risk of wound complications and scar sensitivity. However, no studies have proven benefit over one or the other.
Wolfort SF, Dellon AL. Treatment of recurrent neuroma of the interdigital nerve by implantation of the proximal nerve into muscle in the arch of the foot. J Foot Ankle Surg. 40(6):404-410. doi:10.1016/s1067-2516(01)80009-0.
Wolfort et al. performed a prospective study on 17 neuroma through a plantar approach and achieved an 80% success with return to pre-surgical footwear.
Wolfort SF, Dellon AL. Treatment of recurrent neuroma of the interdigital nerve by implantation of the proximal nerve into muscle in the arch of the foot. J Foot Ankle Surg. 40(6):404-410. doi:10.1016/s1067-2516(01)80009-0.
The dorsal approach, allows immediate weight bearing post-surgery and is better tolerated by patients. Coughlin et al. performed a review of dorsal surgical excision at 5.8 years in 82 patients, of which 85% reported excellent or good outcomes, with 65% remaining pain free at 5.8 years.
Multiple studies have reported lower patient satisfaction with excision of adjacent interdigital space neuromas, although the reasoning behind this is uncertain.
There is no clear consensus on whether both neuroma should be excised. Excision of both neuromas can lead to increased complications related to wound healing and numbness. Some clinicians therefore resort to treating this by excising one of the neuromas and decompressing the adjacent intermetatarsal space. Others believe in sequential excision if required following excision of the more symptomatic neuroma.
11. Failure following Morton’s neuroma surgery
The failure rate following surgical excision has been reported as up to 30%. The main reasons for pain following surgical excision are: incorrect diagnosis, neuroma in adjacent intermetatarsal space, incomplete resection, complex regional pain syndrome or recurrence of the Morton’s neuroma also known as stump neuroma. Factors contributing to recurrence include formation of a new neuroma, adhesions and accessory branches of the digital nerves.
Use of steroid injection is the most commonly used modality for dealing with pain following surgical excision. The mechanism of action is breakdown of scar tissue and adhesions. Dellon and Mackinnon described a technique of implantation of the nerve stump within the muscle. In 60 patients with 78 neuromas, 82% of their cohort had a good to excellent results.
Resection of the neuroma proximally with muscle implantation of the new stump can also be used. Overall the chances of success following revision surgery are much less satisfactory than primary excision.
12. Take home message
Morton’s neuroma is a common cause of forefoot pain. Most cases can initially be managed non surgically. Steroid injections are useful diagnostic and therapeutic non surgical treatment modality. Careful clinical examination, patient selection, pre-operative counselling and surgical technique are the key to success in the management of this condition.
Declaration of competing interest
None.
References
Wu K.K.
Morton’s interdigital neuroma: a clinical review of its etiology, treatment, and results.
Makki D, Haddad BZ, Mahmood Z, Saleem Shahid M, Pathak S, Garnham I. Efficacy of Corticosteroid Injection Versus Size of Plantar Interdigital Neuroma Level of Evidence: II, Prospective Comparative Study. doi:10.3113/FAI.2012.0722.
Markovic M, Bs M. Effectiveness of ultrasound-guided corticosteroid injection in the treatment of morton’s neuroma. Foot Ankle Int. doi:10.3113/FAI.2008.0483.
Wolfort SF, Dellon AL. Treatment of recurrent neuroma of the interdigital nerve by implantation of the proximal nerve into muscle in the arch of the foot. J Foot Ankle Surg. 40(6):404-410. doi:10.1016/s1067-2516(01)80009-0.
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